Large drugmakers with the highest profit margins

Ranked

84

of 412 large drugmakers we cover

Median

−5.2%

Highest

84.2%

ABUS

Range

−97.0% to 84.2%

#	Company	Net margin	Operating margin	Revenue growth (TTM)	Market cap
1	ABUSArbutus Biopharma	84.2%	82.0%	n/m	$831M
2	INVAInnoviva	81.2%	36.9%	+18.8%	$1.5B
3	LGNDLigand Pharmaceuticals	67.9%	32.6%	+54.9%	$6.1B
4	TGTXTG Therapeutics	55.2%	17.1%	+76.1%	$8.3B
5	ZVRAZevra Therapeutics	42.8%	60.5%	+119.4%	$582.6M
6	NRIXNurix Therapeutics	42.0%	41.3%	n/m	$2.8B
7	CRMDCorMedix	40.5%	47.0%	+280.5%	$611.9M
8	LLYEli Lilly and	33.5%	42.2%	+49.6%	$1.2T
9	ACADAcadia Pharmaceuticals	33.4%	7.6%	+11.8%	$3.4B
10	IRWDIronwood Pharmaceuticals	33.4%	60.1%	+26.2%	$571.7M
11	LQDALiquidia	30.7%	37.4%	n/m	$3.8B
12	PTGXProtagonist Therapeutics	29.4%	20.7%	+34.8%	$9B
13	INDVIndivior Pharmaceuticals	26.7%	31.6%	+13.5%	$4.1B
14	AMGNAmgen	23.0%	30.0%	+9.1%	$237.5B
15	JAZZJazz Pharmaceuticals	20.4%	19.5%	+12.6%	$13.9B
16	HRMYHarmony Biosciences	18.9%	24.0%	+24.3%	$2.1B
17	BMYBristol-Myers Squibb	18.9%	23.8%	+3.1%	$125.6B
18	PBHPrestige Consumer Healthcare	15.6%	26.3%	−1.4%	$2.3B
19	PBYIPuma Biotechnology	11.6%	13.2%	−2.9%	$568.9M
20	ANIPANI Pharmaceuticals	11.1%	15.4%	+30.9%	$1.7B
21	AMPHAmphastar Pharmaceuticals	10.8%	15.7%	+1.0%	$1.1B
22	ABBVAbbVie	9.8%	26.2%	+10.4%	$504.8B
23	KNSAKiniksa Pharmaceuticals International	9.6%	11.9%	+58.9%	$6B
24	BIIBBiogen	8.3%	12.3%	+0.3%	$37B
25	PFEPfizer	6.8%	21.7%	−0.2%	$171.2B
26	CORTCorcept Therapeutics	6.6%	0.8%	+16.0%	$9.3B
27	PAHCPhibro Animal Health	6.6%	12.8%	+17.1%	$1.6B
28	ARQTArcutis Biotherapeutics	6.1%	7.4%	+76.1%	$3.9B
29	COLLCollegium Pharmaceutical	5.9%	19.5%	+14.3%	$747.5M
30	AMRXAmneal Pharmaceuticals	5.0%	14.6%	+9.3%	$6.5B
31	MRKMerck	4.8%	9.6%	+4.6%	$358.4B
32	ALKSAlkermes plc.	4.0%	7.0%	+10.8%	$7.3B
33	NATRNatures Sunshine Products	3.7%	6.0%	+6.8%	$213.8M
34	OGNOrganon	3.4%	13.4%	−2.5%	$3.6B
35	ARVNArvinas	2.9%	−5.7%	−15.0%	$477.3M
36	LFVNLifevantage	2.8%	3.3%	−20.1%	$73.4M
37	BMRNBiomarin Pharmaceutical	2.1%	4.4%	+11.2%	$10.8B
38	PCRXPacira BioSciences	2.0%	2.7%	+5.7%	$1.5B
39	ASMBAssembly Biosciences	−0.1%	−11.8%	+125.1%	$404M
40	PTCTPTC Therapeutics	−3.8%	12.5%	−42.8%	$5.1B
41	ELANElanco Animal Health	−4.0%	1.6%	+12.0%	$11.3B
42	XERSXeris Biopharma	−5.1%	10.9%	+36.3%	$1.9B
43	SIGASiga Technologies	−5.2%	−20.8%	−70.1%	$224.2M
44	SRPTSarepta Therapeutics	−6.9%	n/m	−20.4%	$1.9B
45	RMTIRockwell Medical	−7.3%	−6.5%	−21.1%	$28M
46	TVTXTravere Therapeutics	−7.4%	−6.8%	+77.1%	$4.7B
47	MGNXMacrogenics	−8.7%	−24.3%	+11.7%	$143.3M
48	DERMJourney Medical	−9.0%	−4.4%	+20.9%	$141.7M
49	BHCBausch Health Companies	−10.1%	8.1%	+10.1%	$2.4B
50	GILDGilead Sciences	−10.6%	−8.2%	+5.5%	$193.5B
51	EOLSEvolus	−10.8%	−5.9%	+13.9%	$463M
52	MNKDMannkind	−11.1%	2.3%	+30.5%	$1B
53	ARDXArdelyx	−12.4%	−7.9%	+16.8%	$767.5M
54	OPKOpko Health	−12.4%	−8.2%	−11.5%	$1.2B
55	SUPNSupernus Pharmaceuticals	−13.2%	−15.7%	+24.9%	$2.4B
56	HROWHarrow	−13.5%	−1.0%	+21.1%	$1.1B
57	AKBAAkebia Therapeutics	−13.5%	−6.9%	+7.5%	$157.1M
58	AMRNAmarin Corp Plc	−14.6%	−21.9%	−15.1%	$249M
59	GYREGyre Therapeutics	−15.5%	−14.0%	+13.5%	$652.3M
60	ORGOOrganogenesis	−18.4%	−7.8%	+6.5%	$127.8M
61	CYRXCryoport	−20.1%	−21.2%	+12.1%	$910.7M
62	SDGRSchrodinger	−21.0%	−59.2%	+8.9%	$1.8B
63	HRTXHeron Therapeutics	−22.5%	−7.2%	+1.0%	$57.5M
64	EBSEmergent BioSolutions	−23.0%	−8.6%	−9.6%	$319.4M
65	SEPNSepterna	−24.5%	−44.0%	n/m	$1.9B
66	AXSMAxsome Therapeutics	−24.7%	−24.0%	+56.9%	$7.6B
67	AYTUAytu Biopharma	−24.8%	−14.4%	−13.3%	$20.6M
68	MDGLMadrigal Pharmaceuticals	−25.3%	−25.1%	+149.0%	$10B
69	GERNGeron	−33.1%	−25.3%	+24.4%	$719.6M
70	MRVIMaravai Lifesciences	−37.1%	−56.1%	−5.0%	$1.9B
71	PHATPhathom Pharmaceuticals	−41.3%	−17.0%	+110.2%	$464.4M
72	PRGOPERRIGO	−41.9%	−37.7%	−4.2%	$2.2B
73	ZLABZai Lab	−41.9%	−58.7%	+5.1%	$2.7B
74	ARWRArrowhead Pharmaceuticals	−47.8%	−33.8%	+16.8%	$8.2B
75	URGNUroGen Pharma	−51.7%	−35.3%	+100.3%	$1.7B
76	IONSIonis Pharmaceuticals	−64.7%	−68.0%	−7.4%	$7.1B
77	IDYAIDEAYA Biosciences	−74.8%	−92.7%	n/m	$3.3B
78	PRTAProthena Corp Public	−80.7%	n/m	n/m	$421M
79	RAREUltragenyx Pharmaceutical	−81.7%	−73.6%	+17.4%	$1.5B
80	RYTMRhythm Pharmaceuticals	−85.6%	−83.6%	+53.5%	$6.1B
81	SNDXSyndax Pharmaceuticals	−87.5%	−77.0%	+222.7%	$1.2B
82	NUVBNuvation Bio	−88.2%	−81.0%	n/m	$1.6B
83	ENTAEnanta Pharmaceuticals	−96.9%	−90.0%	+0.7%	$339M
84	BBIOBridgeBio Pharma	−97.0%	−69.8%	+202.4%	$13.4B

Not ranked: 90 with not a meaningful number, 74 with a margin moved by items that are not sales, 63 with a quarter missing, 11 with no margin to measure, 9 with under $50M of revenue. 81 companies whose data behind this number has a caveat are left out until it is checked.

A ranking of numbers, not a recommendation. A low multiple can be a bargain or a business in trouble: open the company to see which.