Biotech stocks with the highest profit margins

Ranked

29

of 146 biotech stocks we cover

Median

10.7%

Highest

69.3%

AGEN

Range

−89.1% to 69.3%

#	Company	Net margin	Operating margin	Revenue growth (TTM)	Market cap
1	AGENAgenus	69.3%	27.3%	+30.5%	$285M
2	KRYSKrystal Biotech	54.8%	44.9%	+22.6%	$9.2B
3	UTHRUnited Therapeutics	41.6%	44.4%	+2.5%	$25.2B
4	EXELExelixis	35.3%	39.9%	+9.2%	$16B
5	VRTXVertex Pharmaceuticals	35.0%	38.0%	+10.2%	$132.8B
6	ADMAAdma Biologics	33.0%	43.8%	+8.0%	$2.4B
7	REGNRegeneron Pharmaceuticals	27.9%	24.7%	+9.3%	$82.9B
8	INCYIncyte	27.7%	30.6%	+26.9%	$23.5B
9	HALOHalozyme Therapeutics	24.9%	35.9%	+41.2%	$14.3B
10	PLXProtalix BioTherapeutics	23.5%	28.9%	+30.1%	$205.5M
11	NBIXNeurocrine Biosciences	20.9%	23.6%	+34.4%	$14.5B
12	MGTXMeiraGTx	19.9%	46.3%	n/m	$884.6M
13	ALNYAlnylam Pharmaceuticals	16.8%	20.8%	+95.1%	$30B
14	TECHBIO-TECHNE	15.0%	20.7%	−0.4%	$11.4B
15	ONCBeOne Medicines	10.7%	15.1%	+34.3%	$42.9B
16	VCELVericel	7.9%	6.0%	+23.0%	$2.2B
17	RGENRepligen	5.3%	8.2%	+16.5%	$10B
18	CSBRChampions Oncology	−1.8%	−1.7%	+6.7%	$65.7M
19	IMCRImmunocore	−4.2%	−5.2%	+21.0%	$1.6B
20	FENCFennec Pharmaceuticals	−5.5%	−1.9%	+77.8%	$353.5M
21	TARSTarsus Pharmaceuticals	−7.7%	−8.0%	+105.2%	$3B
22	ADPTAdaptive Biotechnologies	−20.7%	−12.2%	+50.1%	$4.1B
23	TWSTTwist Bioscience	−31.7%	−33.6%	+19.2%	$8.8B
24	BCRXBiocryst Pharmaceuticals	−40.9%	−33.3%	+68.7%	$2B
25	BEAMBeam Therapeutics	−54.7%	n/m	+158.9%	$2.5B
26	NVAXNovavax	−59.9%	−56.6%	−61.6%	$1.6B
27	INSMInsmed	−76.9%	−73.9%	+185.8%	$20.4B
28	VIRVir Biotechnology	−83.0%	−92.4%	n/m	$1.8B
29	IOVAIovance Biotherapeutics	−89.1%	−92.7%	+34.5%	$6.4B

Not ranked: 44 with a margin moved by items that are not sales, 29 with not a meaningful number, 16 with a quarter missing, 3 with no margin to measure. 25 companies whose data behind this number has a caveat are left out until it is checked.

A ranking of numbers, not a recommendation. A low multiple can be a bargain or a business in trouble: open the company to see which.