Axsome Therapeutics profit margin AXSM

Gross, operating and net profit as a share of revenue over the last twelve months, from 2023.

Net margin, 12 months: −24.7%
Operating margin, 12 months: −24.0%
Net margin on a year earlier: +25.2 pts
Peer median: 15.0%

Over the twelve months to Jun 30, 2026, Axsome Therapeutics kept −24.7% of its revenue as net profit, with an operating margin of −24.0% and a gross margin of 93.2%.

The median for 10 large drugmakers of a similar size is 15.0%.

Profit margin over time

GrossOperatingNet

Open the interactive chart, with overlays and comparisons

Fiscal year by fiscal year

Fiscal year	Net margin	Operating margin	Gross margin
FY2025	−28.7%	−26.1%	92.6%
FY2024	−74.5%	−72.7%	91.4%
FY2023	−88.4%	−85.7%	90.4%
FY2022	n/a	n/a	n/a
FY2021	n/a	n/a	n/a
FY2020	n/a	n/a	n/a
FY2019	n/a	n/a	n/a
FY2018	n/a	n/a	n/a
FY2017	n/a	n/a	n/a
FY2016	n/a	n/a	n/a
FY2015	n/a	n/a	n/a

Quarter by quarter

Quarter	Ended	Net margin, 12 months	Change on a year	Operating margin
Q2 FY26	Jun 30, 2026	−24.7%	+25.2 pts	−24.0%
Q1 FY26	Mar 31, 2026	−26.6%	+37.8 pts	−24.4%
Q4 FY25	Dec 31, 2025	−28.7%	+45.8 pts	−26.1%
Q3 FY25	Sep 30, 2025	−40.9%	+51.0 pts	−37.8%
Q2 FY25	Jun 30, 2025	−49.9%	n/a	−46.2%
Q1 FY25	Mar 31, 2025	−64.4%	n/a	−62.5%
Q4 FY24	Dec 31, 2024	−74.5%	+13.9 pts	−72.7%
Q3 FY24	Sep 30, 2024	−91.9%	−1.5 pts	−90.5%
Q2 FY24	Jun 30, 2024	n/a	n/a	n/a
Q1 FY24	Mar 31, 2024	n/a	n/a	n/a
Q4 FY23	Dec 31, 2023	−88.4%	n/a	−85.7%
Q3 FY23	Sep 30, 2023	−90.3%	n/a	−86.6%

Against its peers

Companies in Drug Manufacturers - General nearest Axsome Therapeutics' size, closest first, today.

Company	Profit margin
AXSMAxsome Therapeutics	−24.7%
ALKSAlkermes plc.	4.0%
TGTXTG Therapeutics	55.2%
AMRXAmneal Pharmaceuticals	5.0%
PTGXProtagonist Therapeutics	29.4%
CORTCorcept Therapeutics	6.6%
LGNDLigand Pharmaceuticals	67.9%
KNSAKiniksa Pharmaceuticals International	9.6%
BMRNBiomarin Pharmaceutical	2.1%
JAZZJazz Pharmaceuticals	20.4%
INDVIndivior Pharmaceuticals	26.7%
Peer median	15.0%

Where Axsome Therapeutics ranks

#66of 84Large drugmakers with the highest profit margins

What the profit margin tells you

Profit as a share of revenue at three levels: gross (after making the product), operating (after running the business) and net (after everything, including tax and interest).

Compare within an industry. 10% is superb for a retailer and poor for a software company.

More on Axsome Therapeutics

Valuation data, not investment advice. Prices as of Oct 23, 2026. Reported figures come from the company's filings with the SEC.