Spyre Therapeutics SYRE

Drug Manufacturers - General, Healthcare

$90.33

−2.17%

Market cap: $8B
PE: n/m; a loss over the last year
Forward PE: n/m; not a meaningful number
Price to sales: n/m; one or more of the four quarters through 2026-06-30 missing
EV/EBIT: n/m; a loss over the last year
Revenue, 12 months: n/m; one or more of the four quarters through 2026-06-30 missing
Net margin: n/m; one or more of the four quarters through 2026-06-30 missing
Free cash flow yield: n/m; not a meaningful number

Spyre Therapeutics' trailing earnings are negative, so it has no PE.

Charts

Financials

Income statement for SYRE, by quarter
Income statement	Q3 FY23	Q4 FY23	Q1 FY24	Q2 FY24	Q3 FY24	Q4 FY24	Q1 FY25	Q2 FY25	Q3 FY25	Q4 FY25	Q1 FY26	Q2 FY26
	$0	$0	$0	$0	$0	$0	n/a	n/a	n/a	n/a	n/a	n/a
R&D	$24.7M+106%	$33.7M+136%	$34.9M+154%	$32.6M+88%	$44.7M+81%	$50.5M+50%	$41.6M+19%	$40.1M+23%	$45.2M+1%	$44.6M−12%	$60.4M+45%	$65.5M+63%
SG&A	$8.6M+24%	$14.1M+177%	$12.8M+146%	$11.5M−5%	$10.6M+24%	$10.8M−24%	$11.9M−7%	$11.8M+2%	$11.6M+9%	$12.5M+16%	$15.2M+28%	$16.1M+37%
	−$18.3M−2%	−$45.9M+140%	−$47.8M+154%	−$44.1M−72%	−$55.4M+202%	−$61.3M+33%	−$53.6M+12%	−$41.9M−5%	−$56.9M+3%	−$57.2M−7%	−$45.6M−15%	−$41.6M−1%
Pre-tax income	−$40.1M+117%	−$63.2M+236%	−$43.8M+137%	−$38.8M−82%	−$69M+72%	−$56.3M−11%	−$44.8M+2%	−$36.7M−6%	−$11.2M−84%	−$62.5M+11%	−$69M+54%	−$36.2M−1%
	$3K	$0	$32K	$0	$18K+500%	$1K	−$15K	$0	$0	$0	$0	$0
Net income	−$40.1M+120%	−$63.2M+236%	−$43.9M+138%	−$38.8M−82%	−$69M+72%	−$56.3M−11%	−$44.8M+2%	−$36.7M−6%	−$11.2M−84%	−$62.5M+11%	−$69M+54%	−$36.2M−1%
	$0.86	−$4.05−18%	−$0.72−85%	$0.59−99%	$1.06+23%	−$1.02−75%	−$0.60−17%	−$0.61	−$0.19	−$0.83−19%	−$0.74+23%	−$0.43−30%
	4.3M+14%	15.6M+310%	36.5M+868%	45.3M+1086%	50.9M+1085%	55.3M+254%	60.3M+65%	60.3M+33%	60.4M+19%	75.1M+36%	78.5M+30%	84.7M+40%

EPS, diluted: 9 periods, Q4 FY15 to Q2 FY26: quarter's net income to common over its shares, to the cent.

Diluted shares: 11 periods, Q4 FY15 to Q4 FY25: a loss quarter: its basic count, share-days: the 12-month average less the 9-month, weighted by days.

From each company's 10-Q and 10-K filings, the newest version of each figure. Quarters are as filed (a fourth quarter is the year less its first nine months), fiscal years as the 10-K prints them, restated where a later 10-K restated them, and balance sheet lines as of the period's end. A quarter whose 10-Q isn't filed yet is from the company's results release. Growth is on the same period a year earlier. A dash is a period with no figure for the line: the filing doesn't print it, or it hasn't been read yet.

Peers

Companies in Drug Manufacturers - General nearest Spyre Therapeutics' size, closest first.

Company	Market cap	PE	Its 10y median PE	P/S	Revenue growth	Net margin
SYRESpyre Therapeutics	$8B	n/m	n/a	n/m	n/m	n/m
TGTXTG Therapeutics	$8.3B	19.8×	19.4×	10.4×	+76%	55.2%
ALKSAlkermes plc.	$7.3B	115×	16.0×	4.4×	+11%	4.0%
PTGXProtagonist Therapeutics	$9B	134×	58.3×	31.8×	+35%	29.4%
CORTCorcept Therapeutics	$9.3B	204×	28.3×	11.2×	+16%	6.6%
AMRXAmneal Pharmaceuticals	$6.5B	41.6×	51.5×	2.1×	+9%	5.0%
LGNDLigand Pharmaceuticals	$6.1B	32.3×	37.7×	20.8×	+55%	67.9%
KNSAKiniksa Pharmaceuticals International	$6B	79.1×	85.3×	7.1×	+59%	9.6%
BMRNBiomarin Pharmaceutical	$10.8B	151×	70.6×	3.2×	+11%	2.1%
JAZZJazz Pharmaceuticals	$13.9B	14.6×	20.2×	3.0×	+13%	20.4%
INDVIndivior Pharmaceuticals	$4.1B	12.4×	20.1×	3.1×	+13%	26.7%
Peer median	$7.8B	60.3×	33.0×	5.8×	+15%	15.0%