Ionis Pharmaceuticals PE ratio IONS

Share price divided by earnings per share over the last twelve months, since 2015.

Today, Oct 23, 2026: n/m; losses over the last year
Last meaningful: 120×; Feb 2021
9-year median: 51.9×
9-year range: 16.9× to 380×
Peer median: 97.0×

Ionis Pharmaceuticals has no meaningful PE ratio today: it lost $3.46 a share over the last twelve months, and a PE needs earnings.

It was last meaningful in Feb 2021, at 120×.

On the days it had one over the last 9 years, its median was 51.9×, from 16.9× in Feb 2020 to 380× in Dec 2017.

PE ratio over time

median 51.9×

The dashed line is the 9-year median and the shaded band the middle half of its days.

Open the interactive chart, with overlays and comparisons

Year by year

Year	End of year	Low	High
2021	120×	119×	129×
2020	118×	16.9×	124×
2019	20.3×	19.0×	45.2×
2018	340×	312×	355×
2017	335×	223×	380×
2016	336×	322×	413×
2015	490×	240×	490×

Against its peers

Companies in Drug Manufacturers - General nearest Ionis Pharmaceuticals' size, closest first, today.

Company	PE ratio
IONSIonis Pharmaceuticals	n/m
ALKSAlkermes plc.	115×
AMRXAmneal Pharmaceuticals	41.6×
TGTXTG Therapeutics	19.8×
LGNDLigand Pharmaceuticals	32.3×
KNSAKiniksa Pharmaceuticals International	79.1×
PTGXProtagonist Therapeutics	134×
CORTCorcept Therapeutics	204×
BMRNBiomarin Pharmaceutical	151×
INDVIndivior Pharmaceuticals	12.4×
ARQTArcutis Biotherapeutics	142×
Peer median	97.0×

What the PE ratio tells you

Share price divided by earnings per share over the last twelve months. It is the price tag on a dollar of profit: 20× means you pay $20 for $1 of yearly earnings.

Blank while earnings are negative. A very low PE can mean the market expects profits to fall, so read it with growth and the company's own history.

More on Ionis Pharmaceuticals

Valuation data, not investment advice. Prices as of Oct 23, 2026. Reported figures come from the company's filings with the SEC.