Upstream Bio UPB

Drug Manufacturers - General, Healthcare

$2.74

−8.36%

Market cap: $150.1M
PE: n/m; a loss over the last year
Forward PE: n/m; not a meaningful number
Price to sales: 47.5×
EV/EBIT: n/m; a loss over the last year
Revenue, 12 months: $3.2M; +16% on a year ago
Net margin: n/m; outside −100% to 100%
Free cash flow yield: n/m; not a meaningful number

Upstream Bio trades at 47.5× sales. Its trailing earnings are negative, so it has no PE. Revenue was $3.2M over the last twelve months, up 16% on a year earlier.

Charts

Financials

Income statement for UPB, by quarter
Income statement	Q3 FY23	Q4 FY23	Q1 FY24	Q2 FY24	Q3 FY24	Q4 FY24	Q1 FY25	Q2 FY25	Q3 FY25	Q4 FY25	Q1 FY26	Q2 FY26
	$621K	$450K	$640K	$510K	$607K−2%	$613K+36%	$566K−12%	$937K+84%	$683K+13%	$668K+9%	$1M+83%	$773K−18%
R&D	$7.8M	$11.6M	$11.7M	$14.1M	$15.4M+98%	$21.8M+88%	$25.8M+121%	$37.9M+169%	$33M+114%	$40.2M+85%	$36.6M+42%	$36.1M−5%
SG&A	$2.2M	$3.2M	$4M	$4M	$4.1M+83%	$5.2M+60%	$6.8M+71%	$7.4M+86%	$5.5M+36%	$6.7M+29%	$8.1M+19%	$7.1M−5%
	−$9.4M	−$14.3M	−$15M	−$17.5M	−$18.9M+101%	−$26.3M+84%	−$32M+113%	−$44.3M+153%	−$37.8M+100%	−$46.2M+75%	−$43.6M+36%	−$42.4M−5%
Net income	−$3.1M	−$11.8M	−$10.9M	−$14.7M	−$16M+416%	−$21.2M+80%	−$27.3M+150%	−$40M+172%	−$33.7M+111%	−$42.5M+100%	−$40.6M+49%	−$39.7M−1%
	−$2.11	−$5.03	−$4.68	−$6.50	−$6.96+230%	n/a	−$0.51−89%	−$0.74−89%	−$0.63−91%	−$0.79	−$0.75+47%	−$0.73−1%
	3M	3M	3M	3M	3M+2%	n/a	53.6M+1690%	53.8M+1687%	53.9M+1684%	54.1M	54.3M+1%	54.6M+2%

EPS, diluted: Q4 FY23 and Q4 FY25: quarter's net income to common over its shares, to the cent.

Diluted shares: Q4 FY23 and Q4 FY25: a loss quarter: its basic count, share-days: the 12-month average less the 9-month, weighted by days.

From each company's 10-Q and 10-K filings, the newest version of each figure. Quarters are as filed (a fourth quarter is the year less its first nine months), fiscal years as the 10-K prints them, restated where a later 10-K restated them, and balance sheet lines as of the period's end. A quarter whose 10-Q isn't filed yet is from the company's results release. Growth is on the same period a year earlier. A dash is a period with no figure for the line: the filing doesn't print it, or it hasn't been read yet.

Peers

Companies in Drug Manufacturers - General nearest Upstream Bio's size, closest first.

Company	Market cap	PE	Its 10y median PE	P/S	Revenue growth	Net margin
UPBUpstream Bio	$150.1M	n/m	n/a	47.5×	+16%	n/m
NATRNatures Sunshine Products	$213.8M	12.0×	20.6×	0.4×	+7%	3.7%
LFVNLifevantage	$73.4M	14.7×	19.6×	0.4×	−20%	2.8%
SPROSpero Therapeutics	$64.6M	10.1×	9.5×	1.4×	−3%	15.7%
ATNMActinium Pharmaceuticals	$47.8M	4.2×	3.1×	n/m	n/m	n/m
ARVNArvinas	$477.3M	45.6×	52.3×	1.5×	−15%	2.9%
PBYIPuma Biotechnology	$568.9M	21.2×	12.3×	2.5×	−3%	11.6%
IRWDIronwood Pharmaceuticals	$571.7M	4.5×	14.9×	1.5×	+26%	33.4%
ZVRAZevra Therapeutics	$582.6M	10.5×	12.3×	4.3×	+119%	42.8%
CRMDCorMedix	$611.9M	3.7×	4.0×	1.3×	+281%	40.5%
COLLCollegium Pharmaceutical	$747.5M	18.5×	19.1×	0.9×	+14%	5.9%
Peer median	$523.1M	11.3×	13.6×	1.4×	+7%	11.6%